Quantitative single-molecule study of TGF-&beta;/Smad signaling | Zendy

Rong Zhao | Zendy; Nan Li | Zendy; Jiachao Xu | Zendy; Wenhui Li | Zendy; Xiaohong Fang | Zendy

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Quantitative single-molecule study of TGF-β/Smad signaling

Author(s) -

Rong Zhao,

Nan Li,

Jiachao Xu,

Wenhui Li,

Xiaohong Fang

Publication year - 2017

Publication title -

acta biochimica et biophysica sinica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.771

H-Index - 57

eISSN - 1745-7270

pISSN - 1672-9145

DOI - 10.1093/abbs/gmx121

Subject(s) - smad , signal transduction , cell signaling , tgf beta signaling pathway , microbiology and biotechnology , smad2 protein , cell , transforming growth factor beta , chemistry , biology , computational biology , transforming growth factor , biochemistry

TGF-β/Smad signaling pathway triggers diverse cellular responses among different cell types and environmental conditions. Quantitative analysis of protein-protein interactions involved in TGF-β/Smad signaling is demanded for understanding the molecular mechanism of this signaling pathway. Live-cell single-molecule microcopy with high spatiotemporal resolution is a new tool to monitor key molecular events in a real-time manner. In this review, we mainly presented the recent work on the quantitative characterization of TGF-β/Smad signaling proteins by single-molecule method, and showed how it enabled us to obtain new insights about this canonical signaling process.

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