Osteoclast stimulatory transmembrane protein induces a phenotypic switch in macrophage polarization suppressing an M1 pro-inflammatory state | Zendy

Huimin Yuan | Zendy; Jiangping He | Zendy; Guangya Zhang | Zendy; Dandan Zhang | Zendy; Xiangxin Kong | Zendy; Fengling Chen | Zendy

Open Access

Osteoclast stimulatory transmembrane protein induces a phenotypic switch in macrophage polarization suppressing an M1 pro-inflammatory state

Author(s) -

Huimin Yuan,

Jiangping He,

Guangya Zhang,

Dandan Zhang,

Xiangxin Kong,

Fengling Chen

Publication year - 2017

Publication title -

acta biochimica et biophysica sinica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.771

H-Index - 57

eISSN - 1745-7270

pISSN - 1672-9145

DOI - 10.1093/abbs/gmx092

Subject(s) - macrophage polarization , inflammation , macrophage , gene knockdown , microbiology and biotechnology , phenotype , transmembrane protein , monocyte , biology , macrophage inflammatory protein , chemistry , immunology , biochemistry , in vitro , apoptosis , gene , chemokine , receptor

Macrophages are the key cells in metabolic syndrome and are also a risk factor for metabolic disease. Macrophages have different functions and transcriptional profiles, but all are required for maintaining homeostasis. It is well known that macrophages play a key role in inflammation and early atherogenesis, and are present in two phenotypes: pro-inflammatory (M1) and anti-inflammatory (M2). Osteoclast stimulatory transmembrane protein (oc-stamp) is a multiple-pass transmembrane protein; however, its function remains unclear. In this study, we explored the role of oc-stamp in macrophages physiology. The results showed that oc-stamp was notably decreased under LPS and IFN-γ stimulation, while it was increased with IL-4 treatment. Furthermore, oc-stamp induced a phenotypic switch in macrophage polarization, suppressing the M1 pro-inflammatory state in the overexpression group, and promoting the M1 pro-inflammatory state in the knockdown group. Further study revealed that oc-stamp regulated macrophage polarization possibly via STAT6. Taken together, our results are the first to demonstrate that oc-stamp may play an important role in macrophage polarization and inhibit the M1 pro-inflammatory state.

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