Up-regulation of carcinoembryonic antigen-related cell adhesion molecule 1 in gastrointestinal cancer and its clinical relevance | Zendy

Muqing Zhou | Zendy; Zhiming Jin | Zendy; Yiwen Liu | Zendy; Yiqing He | Zendy; Yan Du | Zendy; Cuixia Yang | Zendy; Yingzhi Wang | Zendy; Jiajie Hu | Zendy; Lian Cui | Zendy; Feng Gao | Zendy; Manlin Cao | Zendy

Open Access

Up-regulation of carcinoembryonic antigen-related cell adhesion molecule 1 in gastrointestinal cancer and its clinical relevance

Author(s) -

Muqing Zhou,

Zhiming Jin,

Yiwen Liu,

Yiqing He,

Yan Du,

Cuixia Yang,

Yingzhi Wang,

Jiajie Hu,

Lian Cui,

Feng Gao,

Manlin Cao

Publication year - 2017

Publication title -

acta biochimica et biophysica sinica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.771

H-Index - 57

eISSN - 1745-7270

pISSN - 1672-9145

DOI - 10.1093/abbs/gmx060

Subject(s) - carcinoembryonic antigen , immunohistochemistry , cell adhesion molecule , carcinogenesis , cancer , pathology , cancer research , tumor progression , gene isoform , biology , gastrointestinal cancer , tumor marker , medicine , colorectal cancer , immunology , gene , biochemistry

Serum carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is dysregulated in various malignant tumors and has been associated with tumor progression. However, the expression and regulatory mechanisms of serum CEACAM1 in gastrointestinal cancer are still unclear. The expression ratio of the CEACAM1-L and CEACAM1-S isoforms has seldom been investigated in gastrointestinal cancer. In this study, we intended to explore the expression and diagnostic value of CEACAM1 in gastrointestinal cancer. Serum CEACAM1 levels were measured by enzyme-linked immunosorbent assay. The protein expression and distribution of CEACAM1 in tumors were examined by immunohistochemical staining. The expression patterns and ratio of CEACAM1-L/S were analyzed by reverse transcription-polymerase chain reaction. The results showed that serum CEACAM1 levels were significantly higher in cancer patients than in healthy controls. CEACAM1 was found in secreted forms within the neoplastic glands, and its expression was more intense at the tumor invasion front. The CEACAM1-L/S (L:S) ratios were up-regulated during tumorigenesis. Our data suggest that the serum level of CEACAM1 may be used to discriminate gastrointestinal cancer patients from health controls.

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