miR-290 contributes to the low abundance of cyclin D1 protein in mouse embryonic stem cells | Zendy

Zizhen Gong | Zendy; Detao Wang | Zendy; Shaoliang Zhu | Zendy; Yuqing Xia | Zendy; Chunsun Fan | Zendy; Botao Zhao | Zendy; Youxin Jin | Zendy

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miR-290 contributes to the low abundance of cyclin D1 protein in mouse embryonic stem cells

Author(s) -

Zizhen Gong,

Detao Wang,

Shaoliang Zhu,

Yuqing Xia,

Chunsun Fan,

Botao Zhao,

Youxin Jin

Publication year - 2017

Publication title -

acta biochimica et biophysica sinica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.771

H-Index - 57

eISSN - 1745-7270

pISSN - 1672-9145

DOI - 10.1093/abbs/gmx049

Subject(s) - embryonic stem cell , biology , microbiology and biotechnology , induced pluripotent stem cell , stem cell , microrna , cyclin d1 , cell cycle , genetics , gene

Mouse miR-290 cluster miRNAs are expressed specifically in early embryos and embryonic germ cells. These miRNAs play critical roles in the maintenance of pluripotency and self-renewal. Here, we showed that Cyclin D1 is a direct target gene of miR-290 cluster miRNAs. Negative relationships between the expression of Cyclin D1 protein and miR-290 cluster miRNAs in pluripotent and non-pluripotent cells, as well as in differentiating CGR8 cells were observed. Inhibition of miR-290 cluster miRNAs could arrest cells at the G1 phase and slow down the cell proliferation in CGR8 mouse stem cells. Since miR-290 cluster miRNAs are the most dominant stem-cell-specific miRNAs, our results revealed an important cause for the absence of Cyclin D1 in mouse embryonic stem cells.

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