Chemical strategies for pancreatic &beta; cell differentiation, reprogramming, and regeneration | Zendy

Xiaojie Ma | Zendy; Saiyong Zhu | Zendy

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Chemical strategies for pancreatic β cell differentiation, reprogramming, and regeneration

Author(s) -

Xiaojie Ma,

Saiyong Zhu

Publication year - 2017

Publication title -

acta biochimica et biophysica sinica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.771

H-Index - 57

eISSN - 1745-7270

pISSN - 1672-9145

DOI - 10.1093/abbs/gmx008

Subject(s) - reprogramming , induced pluripotent stem cell , regeneration (biology) , directed differentiation , microbiology and biotechnology , cellular differentiation , somatic cell , regenerative medicine , stem cell , biology , pancreatic function , pancreas , cell , endocrinology , embryonic stem cell , genetics , gene

Generation of unlimited functional pancreatic β cells is critical for the study of pancreatic biology and treatment of diabetes mellitus. Recent advances have suggested several promising directions, including directed differentiation of pancreatic β cells from pluripotent stem cells, reprogramming of pancreatic β cells from other types of somatic cells, and stimulated proliferation and enhanced functions of existing pancreatic β cells. Small molecules are useful in generating unlimited numbers of functional pancreatic cells in vitro and could be further developed as drugs to stimulate endogenous pancreatic regeneration. Here, we provide an updated summary of recent major achievements in pancreatic β cell differentiation, reprogramming, proliferation, and function. These studies will eventually lead to significant advances in the field of pancreatic biology and regeneration.

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