High mobility group box1 protein is involved in acute inflammation induced by &lt;italic&gt;Clostridium difficile&lt;/italic&gt; toxin A | Zendy

Liu Ji | Zendy; Beilei Zhang | Zendy; Chunli Sun | Zendy; Jun Wang | Zendy; Shan Li | Zendy; Jufang Wang | Zendy

Open Access

High mobility group box1 protein is involved in acute inflammation induced by <italic>Clostridium difficile</italic> toxin A

Author(s) -

Liu Ji,

Beilei Zhang,

Chunli Sun,

Jun Wang,

Shan Li,

Jufang Wang

Publication year - 2016

Publication title -

acta biochimica et biophysica sinica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.771

H-Index - 57

eISSN - 1745-7270

pISSN - 1672-9145

DOI - 10.1093/abbs/gmw038

Subject(s) - hmgb1 , pathogenesis , clostridium difficile , toxin , inflammation , tlr4 , clostridium difficile toxin a , in vivo , in vitro , microbiology and biotechnology , biology , medicine , immunology , antibiotics , biochemistry , genetics

High mobility group box1 (HMGB1), as a damage-associated inflammatory factor, contributes to the pathogenesis of numerous chronic inflammatory and autoimmune diseases. In this study, we explored the role of HMGB1 in CDI (Clostridium difficile infection) by in vivo and in vitro experiments. Our results showed that HMGB1 might play an important role in the acute inflammatory responses to C. difficile toxin A (TcdA), affect early inflammatory factors, and induce inflammation via the HMGB1-TLR4 pathway. Our study provides the essential information for better understanding the molecular mechanisms of CDI and the potential new therapeutic strategies for the treatment of this infection.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research