The pleiotropic role of exchange protein directly activated by cAMP 1 (EPAC1) in cancer: implications for therapeutic intervention | Zendy

Muayad F. Almahariq | Zendy; Fang Mei | Zendy; Xiaodong Cheng | Zendy

Open Access

The pleiotropic role of exchange protein directly activated by cAMP 1 (EPAC1) in cancer: implications for therapeutic intervention

Author(s) -

Muayad F. Almahariq,

Fang Mei,

Xiaodong Cheng

Publication year - 2015

Publication title -

acta biochimica et biophysica sinica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.771

H-Index - 57

eISSN - 1745-7270

pISSN - 1672-9145

DOI - 10.1093/abbs/gmv115

Subject(s) - guanine nucleotide exchange factor , second messenger system , intracellular , gtpase , cancer , cancer cell , cyclic adenosine monophosphate , small molecule , microbiology and biotechnology , adenosine , biology , chemistry , cancer research , biochemistry , genetics , receptor

The pleiotropic second messenger adenosine 3',5'-cyclic monophosphate (cAMP) regulates a myriad of biological processes under both physiological and pathophysiological conditions. Exchange protein directly activated by cAMP 1 (EPAC1) mediates the intracellular functions of cAMP by acting as a guanine nucleotide exchange factor for the Ras-like Rap small GTPases. Recent studies suggest that EPAC1 plays important roles in immunomodulation, cancer cell migration/metastasis, and metabolism. These results, coupled with the successful development of EPAC-specific small molecule inhibitors, identify EPAC1 as a promising therapeutic target for cancer treatments.

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