Hypoxia and cancer cell metabolism | Zendy

De Huang | Zendy; Chenchen Li | Zendy; Huafeng Zhang | Zendy

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Hypoxia and cancer cell metabolism

Author(s) -

De Huang,

Chenchen Li,

Huafeng Zhang

Publication year - 2014

Publication title -

acta biochimica et biophysica sinica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.771

H-Index - 57

eISSN - 1745-7270

pISSN - 1672-9145

DOI - 10.1093/abbs/gmt148

Subject(s) - cancer cell , hypoxia (environmental) , regulator , reprogramming , cancer , biology , metabolism , cell metabolism , tumor microenvironment , microbiology and biotechnology , cell , cancer research , bioinformatics , biochemistry , chemistry , genetics , gene , organic chemistry , oxygen

The past decade has witnessed a rapid accumulation of evidence showing that hypoxic microenvironment, which is typical during cancer development, plays key roles in regulating cancer cell metabolism. In this review, we will focus on the role of hypoxic response, particularly, its master regulator hypoxia-inducible factor-1, in regulating glucose, lipid, as well as amino acid metabolism in cancer cells. We will also discuss the therapeutic opportunities by targeting specific pathways that facilitate metabolic reprogramming in cancer cells.

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