Open AccessSox11 modulates neocortical development by regulating the proliferation and neuronal differentiation of cortical intermediate precursors
Author(s) -
Li Y,
J Wang,
Yongri Zheng,
Yong-Qi Zhao,
Ming Guo,
Qiyu Bao,
Y Zhang,
Lizhuang Yang,
Li Q
Publication year - 2012
Publication title -
acta biochimica et biophysica sinica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.771
H-Index - 57
eISSN - 1745-7270
pISSN - 1672-9145
DOI - 10.1093/abbs/gms045
Subject(s) - corticogenesis , neurogenesis , progenitor cell , gene knockdown , neocortex , neural stem cell , neural development , progenitor , microbiology and biotechnology , neuroscience , cellular differentiation , embryonic stem cell , biology , stem cell , cell culture , gene , genetics
Neural precursor cells play important roles in the neocortical development, but the mechanisms of neural progenitor proliferation, neuronal differentiation, and migration, as well as patterning are still unclear. Sox11, one of SoxC family members, has been reported to be essential for embryonic and adult neurogenesis. But there is no report about the roles of Sox11 in corticogenesis. In order to investigate Sox11 function during cortical development, loss of function experiment was performed in this study. Knockdown of Sox11 by Sox11 siRNA constructs resulted in a diminished neuronal differentiation, but enhanced proliferation of intermediate progenitors. Accompanied with the high expression of Sox11 in the postmitotic neurons, but low expression of Sox11 in the dividing neural progenitors, all the observations indicate that Sox11 induces neuronal differentiation during the neocortical development.