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Neuropeptide Y (NPY) is a ubiquitous endocrine neuropeptide found in vertebrate and invertebrate. In our present work, two NPY-like exocrine conopeptides (designated as cono-NPYs) were first identified in the venom of cone snails. Both cono-NPYs showed sequence characteristics of invertebrate NPYs, suggesting that some exocrine venom peptides are probably evolved from the preexisting endocrine peptides during the evolution of cone snails.

Identification of neuropeptide Y-like conopeptides from the venom of &lt;italic&gt;Conus betulinus&lt;/italic&gt;

Identification of neuropeptide Y-like conopeptides from the venom of <italic>Conus betulinus</italic>