Double role of Fas ligand in the apoptosis of intervertebral disc cells &lt;italic&gt;in vitro&lt;/italic&gt; | Zendy

Dunfu Han | Zendy; Yue Ding | Zendy; Liu Shang-li | Zendy; Gang Wang | Zendy; In-Cheong Si | Zendy; Xinguang Wang | Zendy; Liyang Cui | Zendy; Dongshang Huang | Zendy

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Double role of Fas ligand in the apoptosis of intervertebral disc cells <italic>in vitro</italic>

Author(s) -

Dunfu Han,

Yue Ding,

Liu Shang-li,

Gang Wang,

In-Cheong Si,

Xinguang Wang,

Liyang Cui,

Dongshang Huang

Publication year - 2009

Publication title -

acta biochimica et biophysica sinica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.771

H-Index - 57

eISSN - 1745-7270

pISSN - 1672-9145

DOI - 10.1093/abbs/gmp087

Subject(s) - fas ligand , apoptosis , immune privilege , microbiology and biotechnology , in vitro , chemistry , rna interference , biology , immune system , programmed cell death , rna , immunology , biochemistry , gene

Fas ligand (FasL) may play an important role in maintaining the immune privilege of intervertebral disc (IVD). Besides, it is closely related to the apoptosis of degenerative disc cells. Nowadays, lots of reports have described about the paradoxical effects of FasL, although the effect of FasL on IVD cells is still under debate. In this study, we tried to investigate the effects of FasL on Fas expression and on the apoptosis of nucleus pulposus (NP) cells in Sprague-Dawley rats. The results showed that the expression of Fas in NP cells was significantly increased by the recombinant FasL. Meanwhile, the apoptosis of NP cells increased markedly in a FasL dose-dependent manner. Interestingly, RNA interference results indicated that the increase of Fas expression and the NP cell apoptosis described previously were inhibited by Fas siRNA, suggesting that RNA interference might be one of novel strategies to prevent IVD cells from apoptosis.

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