Open AccessOverexpression of <italic>VCC-1</italic> gene in human hepatocellular carcinoma cells promotes cell proliferation and invasion
Author(s) -
Xiaoli Mu,
Chen Yao,
Shuihai Wang,
Xiang Huang,
Huazhen Pan,
Ming Li
Publication year - 2009
Publication title -
acta biochimica et biophysica sinica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.771
H-Index - 57
eISSN - 1745-7270
pISSN - 1672-9145
DOI - 10.1093/abbs/gmp051
Subject(s) - transfection , cell growth , hepatocellular carcinoma , cancer research , biology , carcinogenesis , cell culture , chemokine , gene , microbiology and biotechnology , immunology , inflammation , biochemistry , genetics
Vascular endothelial growth factor-correlated chemokine 1 (VCC-1), a novel chemokine, is hypothesized to be associated with carcinogenesis. VCC-1 is expressed in hepatocellular carcinoma (HCC) cells, but its function remains unknown. To investigate the molecular effects of VCC-1 on HCC cells, the HCC cell line SMMC7721 was stably transfected with the recombinant plasmid pcDNA3.1/VCC-1. Our data demonstrated that overexpression of VCC-1 in SMMC7721 cells significantly enhanced the cellular proliferation, invasive ability, and tumor growth, when compared with both empty vector control cells and parental cells. These results strongly suggest that VCC-1 plays an important role in SMMC7721 invasion and tumor growth, and indicate that VCC-1 may serve as a potential biomarker for anti-HCC therapies.