Bmi-1, stem cells and cancer | Zendy

Lili Jiang | Zendy; Jun Li | Zendy; Libing Song | Zendy

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Bmi-1, stem cells and cancer

Author(s) -

Lili Jiang,

Jun Li,

Libing Song

Publication year - 2009

Publication title -

acta biochimica et biophysica sinica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.771

H-Index - 57

eISSN - 1745-7270

pISSN - 1672-9145

DOI - 10.1093/abbs/gmp040

Subject(s) - stem cell , biology , regulator , senescence , regulation of gene expression , cell cycle , microbiology and biotechnology , cancer stem cell , transcriptional regulation , cellular differentiation , gene , mechanism (biology) , function (biology) , gene expression , computational biology , genetics , philosophy , epistemology

Bmi-1, a polycomb gene family member, plays an important role in cell cycle regulation, cell immortalization, and cell senescence. Recently, numerous studies have demonstrated that Bmi-1 is involved in the regulation of self-renewal and differentiation of stem cells. However, the molecular mechanism underlying this biological process remains largely unclear. In the present review, we summarized the function of Bmi-1 as a transcriptional regulator of gene expression, with particular reference to stem cells.

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