Open AccessBmi-1, stem cells and cancer
Author(s) -
Lili Jiang,
Jun Li,
Libing Song
Publication year - 2009
Publication title -
acta biochimica et biophysica sinica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.771
H-Index - 57
eISSN - 1745-7270
pISSN - 1672-9145
DOI - 10.1093/abbs/gmp040
Subject(s) - stem cell , biology , regulator , senescence , cancer stem cell , cell cycle , regulation of gene expression , bmi1 , mechanism (biology) , gene , cellular differentiation , transcriptional regulation , microbiology and biotechnology , gene expression , computational biology , cancer research , genetics , philosophy , epistemology
Bmi-1, a polycomb gene family member, plays an important role in cell cycle regulation, cell immortalization, and cell senescence. Recently, numerous studies have demonstrated that Bmi-1 is involved in the regulation of self-renewal and differentiation of stem cells. However, the molecular mechanism underlying this biological process remains largely unclear. In the present review, we summarized the function of Bmi-1 as a transcriptional regulator of gene expression, with particular reference to stem cells.