PEA3 activates VEGF transcription in T47D and SKBR3 breast cancer cells | Zendy

Dong Hua | Zendy; Bobin Chen | Zendy; Mei Bai | Zendy; Hao Yu | Zendy; Xiaohong Wu | Zendy; Wei Jin | Zendy

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PEA3 activates VEGF transcription in T47D and SKBR3 breast cancer cells

Author(s) -

Dong Hua,

Bobin Chen,

Mei Bai,

Hao Yu,

Xiaohong Wu,

Wei Jin

Publication year - 2009

Publication title -

acta biochimica et biophysica sinica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.771

H-Index - 57

eISSN - 1745-7270

pISSN - 1672-9145

DOI - 10.1093/abbs/gmn007

Subject(s) - skbr3 , chromatin immunoprecipitation , cancer research , angiogenesis , vascular endothelial growth factor , transcription factor , transfection , microbiology and biotechnology , biology , promoter , chemistry , breast cancer , vegf receptors , gene expression , cell culture , cancer , gene , human breast , genetics

Vascular endothelial growth factor (VEGF) is a potent stimulator of angiogenesis and a prognostic factor for many tumors, including those of endocrine-responsive tissues such as the breast and uterus. In this study, we found that overexpression of PEA3 could increase VEGF mRNA levels and VEGF promoter activity in human T47D and SKBR3 breast cancer cells. Chromatin immunoprecipitation assay demonstrated that PEA3 could bind to the VEGF promoter in the cells transfected with PEA3 expression vector. PEA3 small interfering RNA attenuated VEGF promoter activity and the binding of PEA3 to the VEGF promoter in T47D and SKBR3 cells. These results indicated that PEA3 could activate VEGF promoter transcription.

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