Regulation of alveolar type 2 stem/progenitor cells in lung injury and regeneration | Zendy

Ailing Wu | Zendy; Hai Song | Zendy

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Regulation of alveolar type 2 stem/progenitor cells in lung injury and regeneration

Author(s) -

Ailing Wu,

Hai Song

Publication year - 2020

Publication title -

acta biochimica et biophysica sinica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.771

H-Index - 57

eISSN - 1745-7270

pISSN - 1672-9145

DOI - 10.1093/abbs/gmaa052

Subject(s) - lung , stem cell , progenitor cell , regeneration (biology) , microbiology and biotechnology , alveolar epithelium , biology , pathology , homeostasis , adult stem cell , immunology , medicine , endothelial stem cell , in vitro , biochemistry

The renewal of lung epithelial cells is normally slow unless the lung is injured. The resident epithelial stem cells rapidly proliferate and differentiate to maintain lung structure and function when the lung is damaged. The alveolar epithelium is characterized by alveolar type 1 (AT1) and alveolar type 2 (AT2) cells. AT2 cells are the stem cells for alveoli, as they can both self-renew and generate AT1 cells. Abnormal proliferation and regulation of AT2 cells will lead to serious lung diseases including cancers. In this review, we focused on the alveolar stem/progenitor cells, the key physiological function of AT2 cells in lung homeostasis and the complicated regulation of AT2 cells in the repairing processes after lung injury.

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