Salidroside inhibits H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt;-induced apoptosis in PC 12 cells by preventing cytochrome &lt;italic&gt;c&lt;/italic&gt; release and inactivating of caspase cascade | Zendy

Lei Cai | Zendy; Hua Wang | Zendy; Qin Li | Zendy; Yunfei Qian | Zendy; Wenbing Yao | Zendy

Open Access

Salidroside inhibits H<sub>2</sub>O<sub>2</sub>-induced apoptosis in PC 12 cells by preventing cytochrome <italic>c</italic> release and inactivating of caspase cascade

Author(s) -

Lei Cai,

Hua Wang,

Qin Li,

Yunfei Qian,

Wenbing Yao

Publication year - 2008

Publication title -

acta biochimica et biophysica sinica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.771

H-Index - 57

eISSN - 1745-7270

pISSN - 1672-9145

DOI - 10.1093/abbs/40.9.796

Subject(s) - salidroside , cytochrome c , apoptosis , cytosol , mitochondrion , caspase 3 , microbiology and biotechnology , chemistry , caspase 9 , biology , programmed cell death , biochemistry , pharmacology , enzyme

We used a rat pheochromocytoma (PC12) cell line to study the effects of salidroside on hydrogen peroxide (H(2)O(2))-induced apoptosis. In PC12 cells, H(2)O(2)-induced apoptosis was accompanied by the down-regulation of Bcl-2, the up-regulation of Bax, the release of mitochondrial cytochrome c to cytosol, and the activation of caspase-3, -8 and -9. However, salidroside suppressed the down-regulation of Bcl-2, the up-regulation of Bax and the release of mitochondrial cytochrome c to cytosol. Moreover, salidroside attenuated caspase-3, -8 and -9 activation, and eventually protected cells against H(2)O(2)-induced apoptosis. Taken together, these results suggest that treatment of PC12 cells with salidroside can block H(2)O(2)-induced apoptosis by regulating Bcl-2 family members and by suppressing cytochrome c release and caspase cascade activation.

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