The Theaflavin Monomers Inhibit the Cancer Cells Growth &lt;italic&gt;in Vitro&lt;/italic&gt; | Zendy

Youying Tu | Zendy; An-Bin Tang | Zendy; Naoharu Watanabe | Zendy

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The Theaflavin Monomers Inhibit the Cancer Cells Growth <italic>in Vitro</italic>

Author(s) -

Youying Tu,

An-Bin Tang,

Naoharu Watanabe

Publication year - 2004

Publication title -

acta biochimica et biophysica sinica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.771

H-Index - 57

eISSN - 1745-7270

pISSN - 1672-9145

DOI - 10.1093/abbs/36.7.508

Subject(s) - theaflavin , chemistry , in vitro , cancer cell , cancer , biochemistry , microbiology and biotechnology , enzyme , polyphenol , biology , genetics , antioxidant

The inhibition effects of tea theaflavins complex (TFs), theaflavin-3-3'-digallate (TFDG), theaflavin-3'-gallate (TF2B), and an unidentified compound (UC) on the growth of human liver cancer BEL-7402 cells, gastric cancer MKN-28 cells and acute promyelocytic leukemia LH-60 cells were investigated. TFs was obtained through the catalysis of catechins with immobilized polyphenols oxidase. TFDG, TF2B and UC were isolated from TFs with high speed countercurrent chromatography (HSCCC). The results showed that TF2B significantly inhibited the growth of all three kinds of cancer cells, TFs, TFDG and UC had some effect on BEL-7402 and MKN-28, but little activity on LH-60. The inhibition effects of TF2B, TFDG, and UC on BEL-7402 and MKN-28 were stronger than TFs. The relationship coefficients between monomer concentration and its inhibition rate against MKN-28 and BEL-7402 were 0.87 and 0.98 for TF2B, 0.96 and 0.98 for UC, respectively. The IC50 values of TFs, TF2B, and TFDG were 0.18, 0.11, and 0.16 mM on BEL-7402 cells, and 1.11, 0.22, and 0.25 mM on MKN-28 cells respectively.

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