Open AccessKeratin 19 interacts with GSK3β to regulate its nuclear accumulation and degradation of cyclin D3
Author(s) -
Pooja Sharma,
Sarah Tiufekchiev,
Victoria Lising,
Soo Kyo Chung,
Jung Soo Suk,
Byung Min Chung
Publication year - 2021
Publication title -
molecular biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.463
H-Index - 225
eISSN - 1939-4586
pISSN - 1059-1524
DOI - 10.1091/mbc.e21-05-0255
Subject(s) - biology , cyclin d , cyclin a2 , cyclin dependent kinase , cyclin e , microbiology and biotechnology , cyclin b , cyclin d3 , cyclin a , cyclin dependent kinase complex , kinase , cyclin , cancer research , cell cycle , biochemistry , cyclin dependent kinase 2 , protein kinase a , cell
Keratin 19 (K19) inhibits glycogen synthase kinase-3β (GSK3β) accumulation in the nucleus, preventing cyclin D3 degradation. K19 physically interacts with GSK3β, and this interaction requires Ser 10 and 35 of K19. Mutating either residues decreased cyclin D3 levels and cell proliferation. The K19–GSK3β–cyclin D3 pathway also regulates the sensitivity of cancer cells to CDK4/6 inhibitors.