Open AccessThe LINC complex is required for endothelial cell adhesion and adaptation to shear stress and cyclic stretch
Author(s) -
Kevin B. Denis,
Jolene I Cabe,
Brooke E Danielsson,
Katie V Tieu,
Carl R. Mayer,
Daniel E. Conway
Publication year - 2021
Publication title -
molecular biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.463
H-Index - 225
eISSN - 1939-4586
pISSN - 1059-1524
DOI - 10.1091/mbc.e20-11-0698
Subject(s) - biology , cytoskeleton , anchoring , focal adhesion , microbiology and biotechnology , cell adhesion , nucleus , adhesion , endothelial stem cell , mechanotransduction , cell , signal transduction , physics , genetics , structural engineering , in vitro , quantum mechanics , engineering
The LINC complex is a critical structure for anchoring the nucleus to the cytoskeleton. It is shown that disruption of the LINC complex results in endothelial cells with impaired cell-cell junctions, impaired focal adhesions, and an inability to adapt to externally applied force.