Open AccessFibronectin fibril alignment is established upon initiation of extracellular matrix assembly
Author(s) -
Carly M. Garrison,
Jean E. Schwarzbauer
Publication year - 2021
Publication title -
molecular biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.463
H-Index - 225
eISSN - 1939-4586
pISSN - 1059-1524
DOI - 10.1091/mbc.e20-08-0533
Subject(s) - fibronectin , biology , extracellular matrix , fibril , microbiology and biotechnology , matrix (chemical analysis) , biophysics , materials science , composite material
Fibronectin (FN) fibril alignment is crucial for tissue function. We show that assembly of aligned fibrils is determined by the polarized localization of matrix assembly sites. Oriented sites progressed into aligned fibrillar adhesions and FN fibrils. TGF-b stimulated aligned FN assembly, providing a mechanism to modulate fibril orientation in vivo.
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