The Multiple Roles of sGP in Ebola Pathogenesis | Zendy

Marc-Antoine de La Vega | Zendy; Gary Wong | Zendy; Gary Kobinger | Zendy; Xiangguo Qiu | Zendy

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The Multiple Roles of sGP in Ebola Pathogenesis

Author(s) -

Marc-Antoine de La Vega,

Gary Wong,

Gary Kobinger,

Xiangguo Qiu

Publication year - 2014

Publication title -

viral immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.777

H-Index - 61

eISSN - 1557-8976

pISSN - 0882-8245

DOI - 10.1089/vim.2014.0068

Subject(s) - ebola virus , pathogenesis , virology , glycoprotein , biology , virulence , ebola vaccine , immunology , virus , gene , genetics

Ebola causes severe hemorrhagic fever in humans and nonhuman primates, and there are currently no approved therapeutic countermeasures. The virulence of Ebola virus (EBOV) may be partially attributed to the secreted glycoprotein (sGP), which is the main product transcribed from its GP gene. sGP is secreted from infected cells and can be readily detected in the serum of EBOV-infected hosts. This review summarizes the multiple roles that sGP may play during infection and highlights the implications for the future design of vaccines and treatments.

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