Open AccessEstablishing a Cohort of Transgender Men and Gender Nonconforming Individuals to Understand the Molecular Impact of Testosterone on Breast Physiology
Author(s) -
Gabrielle M. Baker,
Michael E. Pyle,
Adam M. Tobias,
Richard A. Bartlett,
Jordana Phillips,
Valerie FeinZachary,
Gerburg M. Wulf,
Yujing J. Heng
Publication year - 2019
Publication title -
transgender health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.242
H-Index - 20
eISSN - 2688-4887
pISSN - 2380-193X
DOI - 10.1089/trgh.2019.0040
Subject(s) - transgender , contouring , testosterone (patch) , medicine , cohort , demographics , male breast cancer , breast cancer , medical record , gynecology , cancer , psychology , demography , engineering , engineering drawing , sociology , psychoanalysis
Purpose: To characterize a cohort of transgender men and masculine-centered gender nonconforming individuals who underwent gender-affirming chest-contouring surgeries at our institution between 2013 and 2018. Methods: Demographics, medical history, and breast histopathological assessment for 340 patients were retrieved from medical records. Results: Most of our patients were white, non-Hispanic (75.0%), were taking testosterone (83.2%), and opted for chest-contouring surgery after 12-14 months of testosterone therapy. Ten patients were parous (2.9%). Seventy-nine (23.2%) and 27 (7.9%) patients had a family history of breast cancer or ovarian cancer, respectively. One transgender man was incidentally diagnosed with ductal carcinoma in situ at chest-contouring surgery. Conclusion: Future studies on this cohort will provide valuable insights about the impact of testosterone on breast physiology.
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