Circulating 3-T1AM and 3,5-T2 in Critically Ill Patients: A Cross-Sectional Observational Study | Zendy

Lies Langouche | Zendy; Ina Lehmphul | Zendy; Sarah Vander Perre | Zendy; Josef Köhrle | Zendy; Greet Van den Berghe | Zendy

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Circulating 3-T1AM and 3,5-T2 in Critically Ill Patients: A Cross-Sectional Observational Study

Author(s) -

Lies Langouche,

Ina Lehmphul,

Sarah Vander Perre,

Josef Köhrle,

Greet Van den Berghe

Publication year - 2016

Publication title -

thyroid

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.918

H-Index - 142

eISSN - 1557-9077

pISSN - 1050-7256

DOI - 10.1089/thy.2016.0214

Subject(s) - reverse triiodothyronine , medicine , intensive care unit , triiodothyronine , sepsis , hormone , endocrinology , confounding , critically ill

Critical illness is hallmarked by low circulating thyroxine (T4) and triiodothyronine (T3) concentrations, in the presence of elevated reverse T3 (rT3) and low-normal thyrotropin (TSH), referred to as nonthyroidal illness (NTI). Thyroid hormone (TH) metabolism is substantially increased during NTI, in part explained by enhanced deiodinase 3 (D3) activity. T4- and T3-sulfate concentrations are elevated, due to suppressed D1 activity in the presence of unaltered sulfotransferase activity, and 3,3'-diiodothyronine (3,3'-T2) concentrations are normal. To elucidate further the driving forces behind increased TH metabolism during NTI, two other potential T4 metabolites-3,5-diiodothyronine (3,5-T2) and 3-iodothyronamine (3-T1AM)-were measured and related to their potential TH precursors.

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