Vertical Bone Regeneration with Synthetic Biomimetic Calcium Phosphate onto the Calvaria of Rats | Zendy

Alain Hoornaert | Zendy; Yassine Maazouz | Zendy; David Pastorino | Zendy; Carlos Aparicio | Zendy; Gonzague de Pinieux | Zendy; Borhane H. Fellah | Zendy; MariaPau Ginebra | Zendy; Pierre Layrolle | Zendy

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Vertical Bone Regeneration with Synthetic Biomimetic Calcium Phosphate onto the Calvaria of Rats

Author(s) -

Alain Hoornaert,

Yassine Maazouz,

David Pastorino,

Carlos Aparicio,

Gonzague de Pinieux,

Borhane H. Fellah,

MariaPau Ginebra,

Pierre Layrolle

Publication year - 2018

Publication title -

tissue engineering part c methods

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 70

eISSN - 1937-3392

pISSN - 1937-3384

DOI - 10.1089/ten.tec.2018.0260

Subject(s) - calvaria , biomaterial , regeneration (biology) , calcium , apatite , biomineralization , crystallinity , chemistry , dentistry , biomedical engineering , materials science , anatomy , microbiology and biotechnology , mineralogy , biology , medicine , biochemistry , in vitro , crystallography , organic chemistry , paleontology

This work reports a new bone substitute made of precipitated apatite crystals that resemble in composition and crystallinity to the mineral phase of bone. The bone regeneration capacity of this synthetic biomimetic calcium phosphate (SBCP) was studied by using an original model of vertical bone regeneration with cups on the calvaria of rats. After 4 weeks, a significantly higher bone growth was found with SBCP compared with deproteinized bovine bone matrix and empty controls. This rapid vertical bone regeneration indicated that this new biomaterial is particularly interesting for filling bone defects in oral surgery.

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