Systematic Review to Compare Urothelium Differentiation with Urethral Epithelium Differentiation in Fetal Development, as a Basis for Tissue Engineering of the Male Urethra | Zendy

Petra de Graaf | Zendy; Ebba Linde | Zendy; Peter Rosier | Zendy; Ander Izeta | Zendy; Karl-Dietrich Sievert | Zendy; Jackie Bosch | Zendy; Laetitia M.O. de Kort | Zendy

Open Access

Systematic Review to Compare Urothelium Differentiation with Urethral Epithelium Differentiation in Fetal Development, as a Basis for Tissue Engineering of the Male Urethra

Author(s) -

Petra de Graaf,

Ebba Linde,

Peter Rosier,

Ander Izeta,

Karl-Dietrich Sievert,

Jackie Bosch,

Laetitia M.O. de Kort

Publication year - 2016

Publication title -

tissue engineering part b reviews

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.579

H-Index - 91

eISSN - 1937-3376

pISSN - 1937-3368

DOI - 10.1089/ten.teb.2016.0352

Subject(s) - urothelium , urethra , epithelium , urothelial cell , biology , transitional epithelium , pathology , medicine , urology , urinary bladder , anatomy

Tissue-engineered (TE) urethra is desirable in men with urethral disease (stricture or hypospadias) and shortage of local tissue. Although ideally a TE graft would contain urethral epithelium cells, currently, bladder epithelium (urothelium) is widely used, but morphologically different. Understanding the differences and similarities of urothelium and urethral epithelium could help design a protocol for in vitro generation of urethral epithelium to be used in TE grafts for the urethra.

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