Open AccessEarly Systemic Cellular Immune Response in Children and Young Adults Receiving Decellularized Fresh Allografts for Pulmonary Valve Replacement
Author(s) -
Anneke Neumann,
Samir Sarikouch,
Thomas Breymann,
Serghei Cebotari,
Dietmar Boethig,
Alexander Horke,
Philipp Beerbaum,
Mechthild Westhoff-Bleck,
Harald Bertram,
Masamichi Ono,
I. Tudorache,
Axel Haverich,
Gernot Beutel
Publication year - 2014
Publication title -
tissue engineering. part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 111
eISSN - 1937-335X
pISSN - 1937-3341
DOI - 10.1089/ten.tea.2013.0316
Subject(s) - decellularization , immune system , medicine , cd8 , immunology , andrology , biomedical engineering , tissue engineering
The longevity of homografts is determined by the activation of the recipients' immune system resulting from allogenic antigen exposition. Fresh decellularized pulmonary homografts (DPH) have shown promising early results in pulmonary valve replacement in children and young adults and could potentially avoid significant activation of the immune system, as more than 99% of the donor DNA is removed during the decellularization process. While the humoral immune response to decellularized allografts has been studied, detailed information on the more significant cellular immune response is currently lacking.