Branched Chain Amino Acids Are Associated with Insulin Resistance Independent of Leptin and Adiponectin in Subjects with Varying Degrees of Glucose Tolerance | Zendy

Margery A. Connelly | Zendy; Justyna Wolak-Dinsmore | Zendy; Robin P.F. Dullaart | Zendy

Open Access

Branched Chain Amino Acids Are Associated with Insulin Resistance Independent of Leptin and Adiponectin in Subjects with Varying Degrees of Glucose Tolerance

Author(s) -

Margery A. Connelly,

Justyna Wolak-Dinsmore,

Robin P.F. Dullaart

Publication year - 2017

Publication title -

metabolic syndrome and related disorders

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.598

H-Index - 45

eISSN - 1557-8518

pISSN - 1540-4196

DOI - 10.1089/met.2016.0145

Subject(s) - medicine , adiponectin , insulin resistance , leptin , endocrinology , insulin , amino acid , adipokine , obesity , biochemistry , chemistry

Branched chain amino acids (BCAA) may be involved in the pathogenesis of insulin resistance and are associated with type 2 diabetes mellitus (T2DM) development. Adipokines such as leptin and adiponectin influence insulin resistance and reflect adipocyte dysfunction. We examined the extent to which the association of BCAA with insulin resistance is attributable to altered leptin and adiponectin levels in individuals with varying degrees of glucose tolerance.

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