Vancomycin-Resistant Enterococci: A Review of Antimicrobial Resistance Mechanisms and Perspectives of Human and Animal Health | Zendy

Mohamed O. Ahmed | Zendy; Keith E. Baptiste | Zendy

Open Access

Vancomycin-Resistant Enterococci: A Review of Antimicrobial Resistance Mechanisms and Perspectives of Human and Animal Health

Author(s) -

Mohamed O. Ahmed,

Keith E. Baptiste

Publication year - 2017

Publication title -

microbial drug resistance

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.889

H-Index - 70

eISSN - 1931-8448

pISSN - 1076-6294

DOI - 10.1089/mdr.2017.0147

Subject(s) - antibiotic resistance , antimicrobial , multiple drug resistance , biology , antibiotics , vancomycin resistant enterococci , microbiology and biotechnology , vancomycin , drug resistance , enterococcus , bacteria , genetics , staphylococcus aureus

Vancomycin-resistant enterococci (VRE) are both of medical and public health importance associated with serious multidrug-resistant infections and persistent colonization. Enterococci are opportunistic environmental inhabitants with a remarkable adaptive capacity to evolve and transmit antimicrobial-resistant determinants. The VRE gene operons show distinct genetic variability and apparently continued evolution leading to a variety of antimicrobial resistance phenotypes and various environmental and livestock reservoirs for the most common van genes. Such complex diversity renders a number of important therapeutic options including "last resort antibiotics" ineffective and poses a particular challenge for clinical management. Enterococci resistance to glycopeptides and multidrug resistance warrants attention and continuous monitoring.

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