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A total of 8,072 gram-positive isolates collected from 69 medical centers among all 9 U.S. Census Divisions during the 2015 SENTRY Antimicrobial Surveillance Program were included. Telavancin had minimal inhibitory concentration (MIC) 50 and MIC 90 values of 0.03/0.06 μg/mL, respectively, against methicillin-susceptible (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA). Similar activity was also observed among coagulase-negative staphylococci (MIC 50/90 , 0.03/0.06 μg/ml; 100.0% inhibited by ≤0.12 μg/ml). Telavancin was active against vancomycin-susceptible Enterococcus faecalis (MIC 50/90 , 0.12/0.12 μg/ml) and Enterococcus faecium (MIC 50/90 , 0.03/0.06 μg/ml), but was less active against vancomycin-resistant E. faecium (MIC 90 , &gt;2 μg/ml) and E. faecalis (MIC 90 , &gt;2 μg/ml). Streptococci showed modal MIC results of 0.008 μg/ml (Streptococcus pneumoniae) to 0.015 μg/ml (β-hemolytic streptococci and viridans group streptococci). Potency variations for telavancin within Census Divisions were not observed. Telavancin remains potent in vitro against indicated pathogens recovered from U.S. medical centers (2015).

microbial drug resistance

<i>In Vitro</i> Activity of Telavancin Against Clinically Important Gram-Positive Pathogens from 69 U.S. Medical Centers (2015): Potency Analysis by U.S. Census Divisions

In Vitro Activity of Telavancin Against Clinically Important Gram-Positive Pathogens from 69 U.S. Medical Centers (2015): Potency Analysis by U.S. Census Divisions