Detection of Lion Podoplanin Using the Antitiger Podoplanin Monoclonal Antibody PMab-231 | Zendy

Yukinari Kato | Zendy; Junko Takei | Zendy; Masato Sano | Zendy; Teizo Asano | Zendy; Yusuke Sayama | Zendy; Kazuyuki Uchida | Zendy; Takayuki Nakagawa | Zendy; Mika K. Kaneko | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Detection of Lion Podoplanin Using the Antitiger Podoplanin Monoclonal Antibody PMab-231

Author(s) -

Yukinari Kato,

Junko Takei,

Masato Sano,

Teizo Asano,

Yusuke Sayama,

Kazuyuki Uchida,

Takayuki Nakagawa,

Mika K. Kaneko

Publication year - 2020

Publication title -

monoclonal antibodies in immunodiagnosis and immunotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.309

H-Index - 36

ISSN - 2167-9436

DOI - 10.1089/mab.2020.0008

Subject(s) - podoplanin , monoclonal antibody , immunohistochemistry , alveolar cells , antibody , biology , lung , medicine , immunology

Monoclonal antibodies (mAbs) that specifically target podoplanin (PDPN), a marker for type I alveolar cells, are needed for immunohistochemical analyses. Anti-PDPN mAbs are available for many species, including human, mouse, rat, rabbit, dog, cat, bovine, pig, Tasmanian devil, alpaca, tiger, whale, goat, horse, bear, and sheep PDPNs. However, no antilion PDPN (lioPDPN) antibody has been developed. In this study, possible cross-reaction between available anti-PDPN mAbs and lioPDPN was examined. Immunohistochemical analysis showed that antitiger PDPN mAb PMab-231 (IgG 2a , kappa) reacted with type I alveolar cells from lion lung, indicating that PMab-231 is useful for the detection of lioPDPN.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research