Podoplanin Expression in Canine Melanoma | Zendy

Satoshi Ogasawara | Zendy; Ryusuke Honma | Zendy; Mika K. Kaneko | Zendy; Yuki Fujii | Zendy; Yumiko Kagawa | Zendy; Satoru Konnai | Zendy; Yukinari Kato | Zendy

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Podoplanin Expression in Canine Melanoma

Author(s) -

Satoshi Ogasawara,

Ryusuke Honma,

Mika K. Kaneko,

Yuki Fujii,

Yumiko Kagawa,

Satoru Konnai,

Yukinari Kato

Publication year - 2016

Publication title -

monoclonal antibodies in immunodiagnosis and immunotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.309

H-Index - 36

ISSN - 2167-9436

DOI - 10.1089/mab.2016.0040

Subject(s) - podoplanin , lymphatic system , melanoma , immunohistochemistry , pathology , lymphatic endothelium , monoclonal antibody , stain , cancer research , chemistry , biology , medicine , antibody , immunology , staining

A type I transmembrane protein, podoplanin (PDPN), is expressed in several normal cells such as lymphatic endothelial cells or pulmonary type I alveolar cells. We recently demonstrated that anticanine PDPN monoclonal antibody (mAb), PMab-38, recognizes canine PDPN of squamous cell carcinomas, but does not react with lymphatic endothelial cells. Herein, we investigated whether PMab-38 reacts with canine melanoma. PMab-38 reacted with 90% of melanoma cells (9/10 cases) using immunohistochemistry. Of interest, PMab-38 stained the lymphatic endothelial cells and cancer-associated fibroblasts in melanoma tissues, although it did not stain any lymphatic endothelial cells in normal tissues. PMab-38 could be useful for uncovering the function of PDPN in canine melanomas.

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