Open AccessOcular Distribution and Pharmacokinetics of Lifitegrast in Pigmented Rabbits and Mass Balance in Beagle Dogs
Author(s) -
Jou-Ku Chung,
Elizabeth Spencer,
Matthew Hunt,
Thomas McCauley,
Devin Welty
Publication year - 2017
Publication title -
journal of ocular pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.727
H-Index - 61
eISSN - 1557-7732
pISSN - 1080-7683
DOI - 10.1089/jop.2017.0106
Subject(s) - beagle , pharmacokinetics , cmax , sclera , cornea , conjunctiva , medicine , posterior segment of eyeball , area under the curve , pharmacology , ophthalmology , chemistry , pathology
Lifitegrast is approved in the United States for the treatment of dry eye disease (DED). We assessed lifitegrast's ocular distribution/pharmacokinetic profile in rabbits, and 14 C-lifitegrast mass balance/excretion in dogs.
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