Hybrid Lipid/Polymer Nanoparticles for Pulmonary Delivery of siRNA: Development and Fate Upon In Vitro Deposition on the Human Epithelial Airway Barrier | Zendy

Ivana d’Angelo | Zendy; Gabriella Costabile | Zendy; Estelle Durantie | Zendy; Paola Brocca | Zendy; Valeria Rondelli | Zendy; Annapina Russo | Zendy; Giulia Russo | Zendy; Agnese Miro | Zendy; Fabiana Quaglia | Zendy; Alke PetriFink | Zendy; Barbara RothenRutishauser | Zendy; Francesca Ungaro | Zendy

Open Access

Hybrid Lipid/Polymer Nanoparticles for Pulmonary Delivery of siRNA: Development and Fate Upon In Vitro Deposition on the Human Epithelial Airway Barrier

Author(s) -

Ivana d’Angelo,

Gabriella Costabile,

Estelle Durantie,

Paola Brocca,

Valeria Rondelli,

Annapina Russo,

Giulia Russo,

Agnese Miro,

Fabiana Quaglia,

Alke PetriFink,

Barbara RothenRutishauser,

Francesca Ungaro

Publication year - 2017

Publication title -

journal of aerosol medicine and pulmonary drug delivery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.678

H-Index - 68

eISSN - 1941-2703

pISSN - 1941-2711

DOI - 10.1089/jamp.2017.1364

Subject(s) - plga , biophysics , aerosolization , a549 cell , cytotoxicity , in vitro , chemistry , nanoparticle , materials science , nanotechnology , biochemistry , inhalation , biology , anatomy

Nowadays, the downregulation of genes involved in the pathogenesis of severe lung diseases through local siRNA delivery appears an interesting therapeutic approach. In this study, we propose novel hybrid lipid-polymer nanoparticles (hNPs) consisting of poly(lactic-co-glycolic) acid (PLGA) and dipalmitoyl phosphatidylcholine (DPPC) as siRNA inhalation system.

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