Aerosol Performance and Stability of Liposomes Containing Ciprofloxacin Nanocrystals | Zendy

David Cipolla | Zendy; Huiying Wu | Zendy; Igor Gonda | Zendy; HakKim Chan | Zendy

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Aerosol Performance and Stability of Liposomes Containing Ciprofloxacin Nanocrystals

Author(s) -

David Cipolla,

Huiying Wu,

Igor Gonda,

HakKim Chan

Publication year - 2015

Publication title -

journal of aerosol medicine and pulmonary drug delivery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.678

H-Index - 68

eISSN - 1941-2703

pISSN - 1941-2711

DOI - 10.1089/jamp.2015.1241

Subject(s) - chromatography , dynamic light scattering , pulmonary surfactant , chemistry , liposome , polyvinyl alcohol , vesicle , polysorbate , drug delivery , sonication , centrifugation , zeta potential , nanoparticle , materials science , nanotechnology , membrane , biochemistry , organic chemistry

Previously we showed that the release properties of a liposomal ciprofloxacin (CFI) formulation could be attenuated by incorporation of drug nanocrystals within the vesicles. Rather than forming these drug nanocrystals during drug loading, they were created post manufacture simply by freezing and thawing the formulation. The addition of surfactant to CFI, either polysorbate 20 or Brij 30, provided an additional means to modify the release profile or incorporate an immediate-release or 'burst' component as well. The goal of this study was to develop a CFI formulation that retained its nanocrystalline morphology and attenuated release profile after delivery as an inhaled aerosol.

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