Effect of Flow Rate on In Vitro Aerodynamic Performance of NEXThaler® in Comparison with Diskus® and Turbohaler® Dry Powder Inhalers | Zendy

Francesca Buttini | Zendy; G. Brambilla | Zendy; Diego Copelli | Zendy; Viviana Sisti | Zendy; Anna Balducci | Zendy; Ruggero Bettini | Zendy; Irene Pasquali | Zendy

Open Access

Effect of Flow Rate on In Vitro Aerodynamic Performance of NEXThaler^® in Comparison with Diskus^® and Turbohaler^® Dry Powder Inhalers

Author(s) -

Francesca Buttini,

G. Brambilla,

Diego Copelli,

Viviana Sisti,

Anna Balducci,

Ruggero Bettini,

Irene Pasquali

Publication year - 2015

Publication title -

journal of aerosol medicine and pulmonary drug delivery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.678

H-Index - 68

eISSN - 1941-2703

pISSN - 1941-2711

DOI - 10.1089/jamp.2015.1220

Subject(s) - aerodynamics , dry powder inhaler , flow (mathematics) , physics , inhaler , medicine , mechanics , asthma

European and United States Pharmacopoeia compendial procedures for assessing the in vitro emitted dose and aerodynamic size distribution of a dry powder inhaler require that 4.0 L of air at a pressure drop of 4 kPa be drawn through the inhaler. However, the product performance should be investigated using conditions more representative of what is achievable by the patient population. This work compares the delivered dose and the drug deposition profile at different flow rates (30, 40, 60, and 90 L/min) of Foster NEXThaler(®) (beclomethasone dipropionate/formoterol fumarate), Seretide(®) Diskus(®) (fluticasone propionate/salmeterol xinafoate), and Symbicort(®) Turbohaler(®) (budesonide/formoterol fumarate).

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