Open AccessOne Group's Historical Reflections on DNA Vaccine Development
Author(s) -
Ellen F. Fynan,
Shan Lu,
Harriet L. Robinson
Publication year - 2018
Publication title -
human gene therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.633
H-Index - 149
eISSN - 1557-7422
pISSN - 1043-0342
DOI - 10.1089/hum.2018.066
Subject(s) - dna vaccination , virology , dna , vaccination , skepticism , biology , genetics , philosophy , epistemology , plasmid
DNA vaccines were pioneered by several groups in the early 1990s. This article presents the reflections of one of these groups on their work with retroviral vectors in chickens that contributed to the discovery and early development of DNA vaccines. Although the findings were initially met with skepticism, the work presented here combined with that of others founded a new method of vaccination: the direct inoculation of purified DNA encoding the target antigen.
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