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Synergistic Association of Genetic Variants with Environmental Risk Factors in Susceptibility to Essential Hypertension
Author(s) -
Célia Regina Sousa da Silva,
M I Mendonça,
Andreia Pereira,
Sara Gouveia,
Ana Isabel Freitas,
G Guerra,
Mariana Rodrigues,
E Henriques,
Sónia Freitas,
Sofia Borges,
Décio Pereira,
António Brehm,
Roberto Palma dos Reis
Publication year - 2017
Publication title -
genetic testing and molecular biomarkers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.405
H-Index - 47
eISSN - 1945-0265
pISSN - 1945-0257
DOI - 10.1089/gtmb.2017.0048
Subject(s) - multifactor dimensionality reduction , odds ratio , obesity , essential hypertension , body mass index , diabetes mellitus , genetic predisposition , genetic model , confidence interval , genotype , allele , medicine , genetic association , case control study , logistic regression , disease , genetics , bioinformatics , biology , gene , single nucleotide polymorphism , endocrinology , blood pressure
Essential hypertension (EH) is a disease in which both environment and genes have an important role. This study was designed to identify the interaction model between genetic variants and environmental risk factors that most highly potentiates EH development.

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