CXCR2 Signaling and Remyelination in Preclinical Models of Demyelination | Zendy

Dominic D. Skinner | Zendy; Thomas E. Lane | Zendy

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CXCR2 Signaling and Remyelination in Preclinical Models of Demyelination

Author(s) -

Dominic D. Skinner,

Thomas E. Lane

Publication year - 2019

Publication title -

dna and cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.895

H-Index - 77

eISSN - 1557-7430

pISSN - 1044-5498

DOI - 10.1089/dna.2019.5182

Subject(s) - cxc chemokine receptors , remyelination , biology , cxcl2 , neuroscience , cxcl1 , microglia , chemokine receptor , central nervous system , progenitor cell , chemokine , microbiology and biotechnology , immunology , stem cell , inflammation , myelin

The chemokine receptor CXCR2 is a receptor for CXC chemokines, including CXCL1 and CXCL2. CXCR2 is expressed by resident cells of the central nervous system, including neurons, microglia, oligodendrocyte progenitor cells (OPCs), and oligodendrocytes. CXCR2 signaling is important in regulating OPC biology with regard to positional migration and myelination during development. More recently, studies have argued that CXCR2 is involved in controlling events related to remyelination after experimentally induced demyelination. This review examines the concept that targeting CXCR2 may offer a novel therapeutic target for promoting remyelination.

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