DBCAT: Database of CpG Islands and Analytical Tools for Identifying Comprehensive Methylation Profiles in Cancer Cells | Zendy

Hsien-Chi Kuo | Zendy; PoYu Lin | Zendy; Ting-Chiun Chung | Zendy; Chin-Mei Chao | Zendy; LiangChuan Lai | Zendy; MongHsun Tsai | Zendy; Eric Y. Chuang | Zendy

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DBCAT: Database of CpG Islands and Analytical Tools for Identifying Comprehensive Methylation Profiles in Cancer Cells

Author(s) -

Hsien-Chi Kuo,

PoYu Lin,

Ting-Chiun Chung,

Chin-Mei Chao,

LiangChuan Lai,

MongHsun Tsai,

Eric Y. Chuang

Publication year - 2011

Publication title -

journal of computational biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.585

H-Index - 95

eISSN - 1557-8666

pISSN - 1066-5277

DOI - 10.1089/cmb.2010.0038

Subject(s) - dna methylation , cpg site , methylation , epigenetics , computational biology , biology , microarray , microarray analysis techniques , database , gene , bioinformatics , genetics , computer science , gene expression

DBCAT (database of CpG islands and analytical tools, http://dbcat.cgm.ntu.edu.tw/ ), developed to characterize comprehensive DNA methylation profiles in human cancers, is a web-based application and methylation database containing several convenient tools for investigating epigenetic regulation in human diseases. To our knowledge, DBCAT is the first online methylation analytical tool, and is composed of three parts: a CpG island finder, a genome query browser, and a tool for analyzing methylation microarray data. The analytical tools can quickly identify genes with methylated regions from microarray data, compare the methylation status changes between different arrays, and provide functional analysis in addition to colocalizing transcription factor binding sites.

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