LncRNA GATA6-AS Promotes Cancer Cell Proliferation and Inhibits Apoptosis in Glioma by Downregulating lncRNA TUG1 | Zendy

Yuzhi Liao | Zendy; Baozhong Zhang | Zendy; Ting Zhang | Zendy; Yiming Zhang | Zendy; Fei Wang | Zendy

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LncRNA GATA6-AS Promotes Cancer Cell Proliferation and Inhibits Apoptosis in Glioma by Downregulating lncRNA TUG1

Author(s) -

Yuzhi Liao,

Baozhong Zhang,

Ting Zhang,

Yiming Zhang,

Fei Wang

Publication year - 2019

Publication title -

cancer biotherapy and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.716

H-Index - 59

eISSN - 1557-8852

pISSN - 1084-9785

DOI - 10.1089/cbr.2019.2830

Subject(s) - gata6 , glioma , downregulation and upregulation , cell growth , cancer research , apoptosis , long non coding rna , biology , microbiology and biotechnology , gene expression , genetics , gene

Background: Long noncoding RNA (lncRNA) GATA6-AS regulates the growth of endothelial cells, indicating its involvement in human diseases. The present study aimed to investigate the roles of GATA6-AS in glioma. Results: GATA6-AS was significantly upregulated in glioma. GATA6-AS levels in plasma was positively and significantly correlated with its expression levels in glioma tissues. TUG1 was significantly downregulated in glioma and was inversely correlated with GATA6-AS. GATA6-AS overexpression led to TUG1 downregulation, whereas TUG1 overexpression failed to significantly affect GATA6-AS. GATA6-AS overexpression promoted glioma cell proliferation and inhibited apoptosis, TUG1 overexpression inhibited cell proliferation and attenuated the effects of GATA6-AS overexpression. Conclusions: Therefore, lncRNA GATA6-AS affects cell proliferation and apoptosis and regulates TUG1 expression in glioma.

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