Cannabinoid CB1and CB2Receptor Signaling and Bias | Zendy

Mikkel Søes Ibsen | Zendy; Mark Connor | Zendy; Michelle Glass | Zendy

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Cannabinoid CB₁and CB₂Receptor Signaling and Bias

Author(s) -

Mikkel Søes Ibsen,

Mark Connor,

Michelle Glass

Publication year - 2017

Publication title -

cannabis and cannabinoid research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.156

H-Index - 17

eISSN - 2578-5125

pISSN - 2378-8763

DOI - 10.1089/can.2016.0037

Subject(s) - signal transduction , cannabinoid receptor , cannabinoid , receptor , functional selectivity , agonist , signalling pathways , endocannabinoid system , neuroscience , g protein coupled receptor , biology , microbiology and biotechnology , chemistry , biochemistry

An agonist that acts through a single receptor can activate numerous signaling pathways. Recent studies have suggested that different ligands can differentially activate these pathways by stabilizing a limited range of receptor conformations, which in turn preferentially drive different downstream signaling cascades. This concept, termed "biased signaling" represents an exciting therapeutic opportunity to target specific pathways that elicit only desired effects, while avoiding undesired effects mediated by different signaling cascades. The cannabinoid receptors CB 1 and CB 2 each activate multiple pathways, and evidence is emerging for bias within these pathways. This review will summarize the current evidence for biased signaling through cannabinoid receptor subtypes CB 1 and CB 2 .

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