What Is Life—and When Do We Search for It on Other Worlds

There has been considerable attention on how to detect life on other worlds by searching for biomolecules. However, there has been much less clarity as to when it becomes warranted to focus a mission on the search for life on another world. At a minimum, a life-detection mission should follow convincing evidence of (1) Liquid water of suitable salinity, past or present; (2) Carbon in the water; (3) Biologically available N in the water; (4) Biologically useful energy in the water; (5) Organic material that can possibly be of biological origin and a plausible strategy for sampling this material. Based on these prerequisites, the most promising targets for a life search are currently the plume of Enceladus and the subsurface of Mars-in equatorial lake bed sediments and in polar ice-cemented ground. Neither the surface of Europa nor the clouds of Venus meet the criteria listed here but may with further exploration.