Protection of Kidney Function with Human Antioxidation Protein α1-Microglobulin in a Mouse 177Lu-DOTATATE Radiation Therapy Model | Zendy

Amanda Kristiansson | Zendy; Jonas Ahlstedt | Zendy; Bo Holmqvist | Zendy; Anders Brinte | Zendy; Thuy Tran | Zendy; Eva ForssellAronsson | Zendy; SvenErik Strand | Zendy; Magnus Gram | Zendy; Bo Åkerström | Zendy

Open Access

Protection of Kidney Function with Human Antioxidation Protein α₁-Microglobulin in a Mouse ¹⁷⁷Lu-DOTATATE Radiation Therapy Model

Author(s) -

Amanda Kristiansson,

Jonas Ahlstedt,

Bo Holmqvist,

Anders Brinte,

Thuy Tran,

Eva ForssellAronsson,

SvenErik Strand,

Magnus Gram,

Bo Åkerström

Publication year - 2018

Publication title -

antioxidants and redox signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.277

H-Index - 190

eISSN - 1557-7716

pISSN - 1523-0864

DOI - 10.1089/ars.2018.7517

Subject(s) - beta 2 microglobulin , kidney , function (biology) , chemistry , biology , microbiology and biotechnology , immunology , endocrinology

Peptide receptor radionuclide therapy (PRRT) is in clinical use today to treat metastatic neuroendocrine tumors. Infused, radiolabeled, somatostatin analog peptides target tumors that are killed by irradiation damage. The peptides, however, are also retained in kidneys due to glomerular filtration, and the administered doses must be limited to avoid kidney damage. The human radical scavenger and antioxidant, α 1 -microglobulin (A1M), has previously been shown to protect bystander tissue against irradiation damage and has pharmacokinetic and biodistribution properties similar to somatostatin analogs. In this study, we have investigated if A1M can be used as a renal protective agent in PRRT.

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