Abnormal Golgi pH Homeostasis in Cancer Cells Impairs Apical Targeting of Carcinoembryonic Antigen by Inhibiting Its Glycosyl-Phosphatidylinositol Anchor-Mediated Association with Lipid Rafts | Zendy

Nina Kokkonen | Zendy; Elham Khosrowabadi | Zendy; Antti Hassinen | Zendy; Déborah Harrus | Zendy; Tuomo Glumoff | Zendy; Thomas Kietzmann | Zendy; Sakari Kellokumpu | Zendy

Open Access

Abnormal Golgi pH Homeostasis in Cancer Cells Impairs Apical Targeting of Carcinoembryonic Antigen by Inhibiting Its Glycosyl-Phosphatidylinositol Anchor-Mediated Association with Lipid Rafts

Author(s) -

Nina Kokkonen,

Elham Khosrowabadi,

Antti Hassinen,

Déborah Harrus,

Tuomo Glumoff,

Thomas Kietzmann,

Sakari Kellokumpu

Publication year - 2018

Publication title -

antioxidants and redox signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.277

H-Index - 190

eISSN - 1557-7716

pISSN - 1523-0864

DOI - 10.1089/ars.2017.7389

Subject(s) - lipid raft , golgi apparatus , microbiology and biotechnology , chemistry , epithelial polarity , cancer cell , carcinoembryonic antigen , biology , biochemistry , cell , cancer , signal transduction , genetics

Carcinoembryonic antigen (CEACAM5, CEA) is a known tumor marker for colorectal cancer that localizes in a polarized manner to the apical surface in normal colon epithelial cells whereas in cancer cells it is present at both the apical and basolateral surfaces of the cells. Since the Golgi apparatus sorts and transports most proteins to these cell surface domains, we set out here to investigate whether any of the factors commonly associated with tumorigenesis, including hypoxia, generation of reactive oxygen species (ROS), altered redox homeostasis, or an altered Golgi pH, are responsible for mistargeting of CEA to the basolateral surface in cancer cells.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research