Redox-Driven Signaling: 2-Oxo Acid Dehydrogenase Complexes as Sensors and Transmitters of Metabolic Imbalance | Zendy

Victoria I. Bunik | Zendy

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Redox-Driven Signaling: 2-Oxo Acid Dehydrogenase Complexes as Sensors and Transmitters of Metabolic Imbalance

Author(s) -

Victoria I. Bunik

Publication year - 2018

Publication title -

antioxidants and redox signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.277

H-Index - 190

eISSN - 1557-7716

pISSN - 1523-0864

DOI - 10.1089/ars.2017.7311

Subject(s) - reactive oxygen species , chemistry , superoxide , biochemistry , glutaredoxin , nad+ kinase , dehydrogenase , thioredoxin reductase , dihydrolipoamide dehydrogenase , radical , redox , thioredoxin , enzyme , organic chemistry

This article develops a holistic view on production of reactive oxygen species (ROS) by 2-oxo acid dehydrogenase complexes. Recent Advances: Catalytic and structural properties of the complexes and their components evolved to minimize damaging effects of side reactions, including ROS generation, simultaneously exploiting the reactions for homeostatic signaling.

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