Calcium Release Mediated by Redox-Sensitive RyR2 Channels Has a Central Role in Hippocampal Structural Plasticity and Spatial Memory | Zendy

Jamileth More | Zendy; Bárbara Bruna | Zendy; Pedro Lobos | Zendy; José Luis Galaz | Zendy; Paula Figueroa | Zendy; Silvia Namias | Zendy; Gina Sánchez | Zendy; Genaro Barrientos | Zendy; José L. Valdés | Zendy; Andrea Paula-Lima | Zendy; Cecilia Hidalgo | Zendy; Tatiana Adasme | Zendy

Open Access

Calcium Release Mediated by Redox-Sensitive RyR2 Channels Has a Central Role in Hippocampal Structural Plasticity and Spatial Memory

Author(s) -

Jamileth More,

Bárbara Bruna,

Pedro Lobos,

José Luis Galaz,

Paula Figueroa,

Silvia Namias,

Gina Sánchez,

Genaro Barrientos,

José L. Valdés,

Andrea Paula-Lima,

Cecilia Hidalgo,

Tatiana Adasme

Publication year - 2018

Publication title -

antioxidants and redox signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.277

H-Index - 190

eISSN - 1557-7716

pISSN - 1523-0864

DOI - 10.1089/ars.2017.7277

Subject(s) - ryanodine receptor , downregulation and upregulation , ryanodine receptor 2 , chemistry , microbiology and biotechnology , hippocampal formation , biology , neuroscience , receptor , biochemistry , gene

Previous studies indicate that hippocampal synaptic plasticity and spatial memory processes entail calcium release from intracellular stores mediated by ryanodine receptor (RyR) channels. In particular, RyR-mediated Ca 2+ release is central for the dendritic spine remodeling induced by brain-derived neurotrophic factor (BDNF), a neurotrophin that stimulates complex signaling pathways leading to memory-associated protein synthesis and structural plasticity. To examine if upregulation of ryanodine receptor type-2 (RyR2) channels and the spine remodeling induced by BDNF entail reactive oxygen species (ROS) generation, and to test if RyR2 downregulation affects BDNF-induced spine remodeling and spatial memory.

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