“Only a Life Lived for Others Is Worth Living”: Redox Signaling by Oxygenated Phospholipids in Cell Fate Decisions | Zendy

Yulia Y. Tyurina | Zendy; Indira H. Shrivastava | Zendy; Vladimir A. Tyurin | Zendy; Gaowei Mao | Zendy; Haider H. Dar | Zendy; Simon C. Watkins | Zendy; Michael W. Epperly | Zendy; İvet Bahar | Zendy; Anna A. Shvedova | Zendy; Bruce R. Pitt | Zendy; Sally E. Wenzel | Zendy; Rama K. Mallampalli | Zendy; Yoel Sadovsky | Zendy; Dmitry I. Gabrilovich | Zendy; Joel S. Greenberger | Zendy; Hülya Bayır | Zendy; Valerian E. Kagan | Zendy

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“Only a Life Lived for Others Is Worth Living”: Redox Signaling by Oxygenated Phospholipids in Cell Fate Decisions

Author(s) -

Yulia Y. Tyurina,

Indira H. Shrivastava,

Vladimir A. Tyurin,

Gaowei Mao,

Haider H. Dar,

Simon C. Watkins,

Michael W. Epperly,

İvet Bahar,

Anna A. Shvedova,

Bruce R. Pitt,

Sally E. Wenzel,

Rama K. Mallampalli,

Yoel Sadovsky,

Dmitry I. Gabrilovich,

Joel S. Greenberger,

Hülya Bayır,

Valerian E. Kagan

Publication year - 2017

Publication title -

antioxidants and redox signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.277

H-Index - 190

eISSN - 1557-7716

pISSN - 1523-0864

DOI - 10.1089/ars.2017.7124

Subject(s) - polyunsaturated fatty acid , phospholipid , biochemistry , microbiology and biotechnology , chemistry , cell , mitochondrion , biology , fatty acid , membrane

Oxygenated polyunsaturated lipids are known to play multi-functional roles as essential signals coordinating metabolism and physiology. Among them are well-studied eicosanoids and docosanoids that are generated via phospholipase A 2 hydrolysis of membrane phospholipids and subsequent oxygenation of free polyunsaturated fatty acids (PUFA) by cyclooxygenases and lipoxygenases. Recent Advances: There is an emerging understanding that oxygenated PUFA-phospholipids also represent a rich signaling language with yet-to-be-deciphered details of the execution machinery-oxygenating enzymes, regulators, and receptors. Both free and esterified oxygenated PUFA signals are generated in cells, and their cross-talk and inter-conversion through the de-acylation/re-acylation reactions is not sufficiently explored.

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