Metabolic Regulation of Adipose Tissue Macrophage Function in Obesity and Diabetes | Zendy

Mahesh Appari | Zendy; Keith M. Chan | Zendy; Eileen McNeill | Zendy

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Metabolic Regulation of Adipose Tissue Macrophage Function in Obesity and Diabetes

Author(s) -

Mahesh Appari,

Keith M. Chan,

Eileen McNeill

Publication year - 2017

Publication title -

antioxidants and redox signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.277

H-Index - 190

eISSN - 1557-7716

pISSN - 1523-0864

DOI - 10.1089/ars.2017.7060

Subject(s) - macrophage , adipose tissue , inflammation , adipose tissue macrophages , proinflammatory cytokine , insulin resistance , biology , type 2 diabetes , immunology , pathogenesis , phenotype , diabetes mellitus , white adipose tissue , endocrinology , in vitro , biochemistry , gene

Obesity and diabetes are associated with chronic activation of inflammatory pathways that are important mechanistic links between insulin resistance (IR), type 2 diabetes (T2D), and cardiovascular disease pathogenesis. The development of these metabolic diseases is associated with changes in both the number and phenotype of adipose tissue macrophages (ATMs). Emerging lines of evidence have shown that ATMs release proinflammatory cytokines similar to classically activated M1 macrophages, which directly contribute to IR or T2D. In contrast, adipose tissue (AT) from lean healthy individuals contains macrophages with a less inflammatory M2 phenotype. Recent Advances: Recent research has shown that macrophage phenotype is linked to profound changes in macrophage cellular metabolism.

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