Mammalian Circadian Period, But Not Phase and Amplitude, Is Robust Against Redox and Metabolic Perturbations | Zendy

Marrit Putker | Zendy; Priya Crosby | Zendy; Kevin A. Feeney | Zendy; Nathaniel P. Hoyle | Zendy; Ana S.H. Costa | Zendy; Edoardo Gaude | Zendy; Christian Frezza | Zendy; John S. O’Neill | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Mammalian Circadian Period, But Not Phase and Amplitude, Is Robust Against Redox and Metabolic Perturbations

Author(s) -

Marrit Putker,

Priya Crosby,

Kevin A. Feeney,

Nathaniel P. Hoyle,

Ana S.H. Costa,

Edoardo Gaude,

Christian Frezza,

John S. O’Neill

Publication year - 2017

Publication title -

antioxidants and redox signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.277

H-Index - 190

eISSN - 1557-7716

pISSN - 1523-0864

DOI - 10.1089/ars.2016.6911

Subject(s) - circadian rhythm , circadian clock , biology , flux (metallurgy) , microbiology and biotechnology , redox , metabolism , per2 , biochemistry , pentose phosphate pathway , clock , glycolysis , chemistry , endocrinology , organic chemistry

Circadian rhythms permeate all levels of biology to temporally regulate cell and whole-body physiology, although the cell-autonomous mechanism that confers ∼24-h periodicity is incompletely understood. Reports describing circadian oscillations of over-oxidized peroxiredoxin abundance have suggested that redox signaling plays an important role in the timekeeping mechanism. Here, we tested the functional contribution that redox state and primary metabolism make to mammalian cellular timekeeping.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research