The Neuroprotective Effect of Dimethyl Fumarate in an MPTP-Mouse Model of Parkinson's Disease: Involvement of Reactive Oxygen Species/Nuclear Factor-κB/Nuclear Transcription Factor Related to NF-E2 | Zendy

Michela Campolo | Zendy; Giovanna Casili | Zendy; Flavia Biundo | Zendy; Rosalia Crupi | Zendy; Marika Cordaro | Zendy; Salvatore Cuzzocrea | Zendy; Emanuela Esposito | Zendy

Open Access

The Neuroprotective Effect of Dimethyl Fumarate in an MPTP-Mouse Model of Parkinson's Disease: Involvement of Reactive Oxygen Species/Nuclear Factor-κB/Nuclear Transcription Factor Related to NF-E2

Author(s) -

Michela Campolo,

Giovanna Casili,

Flavia Biundo,

Rosalia Crupi,

Marika Cordaro,

Salvatore Cuzzocrea,

Emanuela Esposito

Publication year - 2016

Publication title -

antioxidants and redox signaling

Language(s) - English

Resource type - Journals

eISSN - 1557-7716

pISSN - 1523-0864

DOI - 10.1089/ars.2016.6800

Subject(s) - neuroprotection , dimethyl fumarate , oxidative stress , chemistry , pharmacology , mptp , tyrosine hydroxylase , nitric oxide synthase , reactive oxygen species , dopamine , heme oxygenase , dopaminergic , biochemistry , biology , endocrinology , immunology , enzyme , heme , multiple sclerosis

Oxidative stress plays a key role in Parkinson disease (PD), and nuclear transcription factor related to NF-E2 (Nrf-2) is involved in neuroprotection against PD. The aim of the present study was to investigate a role for nuclear factor-κB (NF-κB)/Nrf-2 in the neurotherapeutic action of dimethyl fumarate (DMF) in a mouse model of PD and in vitro in SHSY-5Y cells.

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